What distinguishes successful schizophrenia clinical development programs from those that do not progress beyond Phase II?
This live online event will examine approaches to de-risking schizophrenia clinical trials using lessons learned from recent trials as well as new opportunities made possible by AI technology and methodological innovations.
September 24, 2025
8AM PDT | 11AM EDT | 4PM BST | 5PM CET


Dr. Jeffrey A. Lieberman
Dr. Lieberman, who led the landmark CATIE trial and serves as co-chair of Signant's psychiatry scientific advisory board, will moderate a distinguished panel of CNS experts. Together, they will examine critical factors in study design and methodologies that differentiate successful schizophrenia programs from those that discontinue development.
Don’t miss this opportunity to gain practical insights about:
Ensuring patient eligibility and inclusion/exclusion criteria adherence
Optimizing site selection and investigator training for CNS endpoints
Enhancing assessment sensitivity and reliability of psychiatric assessment ratings
Implementing digital measurement solutions
Addressing placebo response in schizophrenia and CNS studies
Avoiding pitfalls when transitioning from successful Phase II to Phase III
Registration Benefits:
Practical Tips and Strategies:
Implementable tools for immediate use
Live Q&A Session:
Ask the presenters questions and gain insights
Exclusive Resources:
Access to post-event materials and recordings
Meet the Panel

David Daniel, MD
Executive Advisor, Schizophrenia
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Alan Kott, MuDR
Practice Leader, Data Analytics
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Christopher Murphy, PhD
Associate Director, Clinical Operations

Navigating CNS Clinical Development:
De-Risking Strategies for Schizophrenia Programs
Wednesday September 24, 2025
8AM PDT | 11AM EDT | 4PM BST | 5PM CET
WHO IS SIGNANT HEALTH
Signant Health is the evidence generation company. We are focused on leveraging software, deep therapeutic and scientific knowledge, and operational expertise to consistently capture, aggregate, and reveal quality evidence for clinical studies across traditional, virtual, and hybrid trial models. For more than 25 years, over 600 sponsors and CROs of all sizes – including all Top 20 pharma – have trusted Signant solutions for remote and site-based eCOA, EDC, eConsent, RTSM, supply chain management, and data quality analytics.
Learn more at www.signanthealth.com