One Platform.
 Every CNS Protocol.

Rater Station covers every CNS indication, every study design, and every phase of clinical development within a single integrated platform.

DISCUSS YOUR PROTOCOL

The Challenge of CNS Endpoint Data

CNS trials present unique measurement challenges. ClinRO scales are complex instruments, and reliable endpoint data depends on consistent administration, accurate scoring, correct patient eligibility, and controlled rater variability - enforced across every site, rater, and visit. Those demands hold whether the study is a Phase II mood disorder program or a complex novel mechanism protocol with functional unblinding risk. Rater Station is built to address all of them.  

Science Encoded in the Technology

This is proven technology, trusted by leading global pharmaceutical companies. 

Structured workflows

Rater Station® guides administration of the full range of CNS scales through structured workflows, with automated scoring validation and scientifically informed edit checks that monitor internal consistency based on the clinical logic built into each scale.

Eligibility verification

Eligibility verification with automatic alerts prevents inappropriate patient inclusion.

Integrated A/V recording

Integrated A/V recording of interviews enables seamless expert central review of scale administration and scoring quality to drive continued endpoint quality throughout each trial.

Automated rater gating

The software implements automated rater gating to ensure only certified raters conduct assessments.

What This Means for Your Study

When scientific rigor is encoded in the technology itself, data quality does not rest solely on individual raters. 


Eligibility errors are caught early.

Eligibility errors are caught early.


Scoring inconsistencies surface in real time.

Scoring inconsistencies surface in real time.

A/V recordings and immediate access to clean source data enable timely expert central review.

A/V recordings and immediate access to clean source data enable timely expert central review.

Rater Station maintains quality proactively throughout the entire study lifecycle.

Rater Station maintains quality proactively throughout the entire study lifecycle.

A Track Record That
Validates the Approach

The platform has supported regulatory submissions across 70+ CNS indications, including mood disorders, schizophrenia, Alzheimer’s, and novel mechanisms including psychedelics and ketamine. The impact of our rater training services has been documented in peer-reviewed literature, demonstrating measurable improvements in inter- and intra-rater variability.

230+ 

TRIALS

70+ 

INDICATIONS

70K+ 

PATIENTS

Campaign - Rater Station - Complete CNS Trial Solutions (2)

 

Let's discuss your protocol

Frequently Asked Questions

Does Rater Station support the full range of CNS scales, including specialist instruments?
Yes. Rater Station's scale library spans the full spectrum of CNS clinical research including psychiatry, neurology, neurodegeneration, pediatric CNS, and novel mechanism studies, complete with built-in scale-specific workflows and scientifically informed edit checks.
How does Signant address the functional unblinding risk in psychedelic and ketamine studies?
Functional unblinding is among the most significant challenges in psychedelic and ketamine research. Signant deploys expert central raters, independent of study sites and blinded to treatment assignment, to administer or review assessments and eliminate potential site-rater bias due to functional unblinding. With 35+ psychedelics trials successfully delivered, Signant brings the scientific expertise and operational experience these protocols require.
How does Rater Station enable real-time visibility into endpoint data quality?
Rater Station provides immediate access to clean source data, enabling proactive identification of endpoint data quality risks throughout the study. Used alongside PureSignal Analytics, Signant's in-house clinicians interpret findings in clinical context and intervene directly with sites and raters to ensure endpoint reliability before issues impact signal detection.
How does Rater Station ensure only qualified raters access study assessments?
Rater Station's automated rater gating ensures raters who have not successfully completed training and qualification are actively blocked from accessing patient assessments, not merely tracked. Ongoing in-study performance monitoring, recalibration, and targeted remediation ensure qualification standards are maintained throughout the study lifecycle.

WHO IS SIGNANT HEALTH


Signant Health is the evidence generation company, leveraging software, deep therapeutic and scientific knowledge, and operational expertise to deliver quality evidence across traditional, virtual, and hybrid trial models. For over 25 years, 600+ sponsors and CROs of all sizes – including all Top 20 pharma – have trusted Signant’s comprehensive eClinical solutions. Our clinical outcome assessments (eCOA, clinician ratings, cognitive testing) and wearable digital health technologies powered by Ametris provide the industry's most comprehensive evidence generation capabilities, alongside EDC, eConsent, RTSM, supply chain management, and data quality analytics. Learn more at www.signanthealth.com.